Novo Nordisk is dropping the cash-pay price of its blockbuster GLP-1 drugs Wegovy and Ozempic from $499 per month to $349 for existing patients. Novo is betting on lower prices to lure some patients away from Zepbound. However, Lilly’s D2C strategy for Zepbound is working—the drugmaker said that about 35% of new Zepbound prescriptions are from the self-pay channel. It’s a signal that most patients who are prescribed Zepbound aren’t asking to switch to Wegovy. That could shift if the price gap between the two drugs widens.

GoodRx is launching a weight loss telehealth membership plan and discounting the cash-pay price for low doses of Novo Nordisk’s Ozempic and Wegovy to $199 per month. GoodRx is newer to telehealth, but already making waves and forging closer relationships with drugmakers.

Hours after online healthcare company Mangoceuticals claimed partnerships with Novo Nordisk and Eli Lilly to provide discounted weight loss drugs to cash-pay customers, both drugmakers denied any affiliation. As GLP-1 compounders lose their pricing edge, smaller players must resist overstating their ties to Novo and Lilly. While any healthcare provider can prescribe Lilly’s or Novo’s GLP-1s, manufacturer-set discounts won’t be made available to companies that engage in misleading marketing.

Eli Lilly will no longer offer CVS Health’s prescription drug benefit plan for its employees, per Bloomberg. Lilly may have been considering another pharmacy benefits manager outside of this news. But it’s more likely that CVS’ choice to promote a rival drug (Wegovy) over Zepbound was Lilly’s breaking point—showing that even employee benefit plans can be used as leverage in the battle for weight loss drug dominance.

Pfizer beat Novo Nordisk in the battle to acquire obesity drugmaker Metsera in a deal worth over $10 billion. Regulators will keep a close watch on mergers to ensure competition in the obesity drug category that could reach $150 billion within 10 years. Leading weight loss drug manufacturers Novo and Eli Lilly will have to lean further into organic development and seek additional clinical indications beyond obesity, while Big Pharmas without weight loss treatments and smaller players could be better off pursuing partnerships and M&As.

Hims & Hers said on its recent earnings call that it’s in active talks with Novo Nordisk to make Wegovy available on Hims’ platforms. Hims and Novo both have an incentive to reignite their partnership. Hims’ pricing edge in the GLP-1 market is fading, while Novo could use GLP-1 sales from Hims’ sticky customer base to make up some of the market share it has recently lost to Lilly.

Novo Nordisk and Eli Lilly struck a deal with the Trump administration to lower GLP-1 prices in exchange for expanded Medicare and Medicaid coverage. It’s by far the most consequential pharma agreement to date For Novo and Lilly, it’s a tradeoff: lower prices for higher patient and prescription volume—a bet that should pay off over time, especially since tariff relief is part of the deal.

Hims & Hers is offering prescription microdoses of compounded GLP-1 semaglutide, joining other telehealth companies touting mini doses with lower costs and fewer side effects. As patients and providers move to try lower-cost doses with fewer side effects, some demand may shift from full-strength prescriptions. That puts pressure on Novo and Lilly to engage physicians around maintenance dosing and longer term patient retention strategies.

Between 2022 and 2024, Novo Nordisk spent about $7.5 million to have Ozempic ads run on related search keywords to drive users to its prescription drug brand website, according to a JAMA Network Open study. Novo spent the $7.5 million across 15,000 paid keywords related to weight loss, which generated 2.4 million paid visits to Ozempic.com. Some drugmakers might be getting away with pay-per-click drug advertising that promotes their product for off-label use. Given that pharma companies devote about 56% of their annual digital ad spend to search—the second-highest share of any sector—marketers should work with search platforms to better align paid keywords with appropriate drug ad placements.

Novo Nordisk entered the escalating acquisition battle for Metsera with a rival offer of up to $9 billion, topping Pfizer's earlier $7.3 billion bid. The Metsersa takeover clash signals how difficult and costly it will be for some companies to enter the weight loss drug category through M&A. Developing novel obesity drugs that offer a significant advantage over current GLP-1s is challenging (see: Pfizer), but it could be the better option for some pharma firms that want to avoid potentially messy, drawn-out bidding wars.

Eli Lilly is partnering with chipmaker NVIDIA to build the pharma industry’s most powerful supercomputer. Lily claims it will be the largest AI factory owned by a pharma company and will be up and running in January 2026. Lilly’s partnership with NVIDIA highlights the shift pharma companies are making to rely on tech firms who have the computing power and AI expertise pharma needs to stay competitive.

Eli Lilly is already manufacturing its not-yet-approved GLP-1 pill for weight loss in anticipation of strong global demand next year. Lilly’s proactive approach puts them in the lead for now, but the GLP-1 and next generation obesity drug market is still in the early stages. Drugmakers need to focus on value-priced messaging and creating accessible weight loss drug brands.

President Donald Trump remarked late last week that the cost of brand-name GLP-1 drugs could drop to $150 in the US. Trump didn’t detail which insurance markets the lower-cost GLP-1s would apply to, or how he plans to force Novo Nordisk and Eli Lilly to drop their prices. With prescriptions surging, GLP-1 drugmakers must prepare for tougher scrutiny and calls from the government, doctors, and patients alike to make treatments more affordable. Pharma marketers should intensify messaging around their weight loss drugs being cost-effective over the long haul by preventing more serious chronic diseases.

Pharma brands are partnering with Reddit to engage with patients more directly, according to a panel discussion at last week’s Advertising Week New York event. Healthcare and pharma brands need to be on Reddit, where communities actively discuss wellness, medications, and medical services. However, healthcare and pharma marketers must avoid obvious promotions, and instead post information that can help people while conducting their own Q&As hosted by company leaders with medical credentials.

Amgen debuted a new direct-to-consumer (D2C) prescription drug platform and cash-pay discounts beginning with heart disease med Repatha. It joins more than half a dozen pharma company D2C launches under pressure from the Trump administration to lower prices through direct sales. Drugmakers need to ensure physicians understand the new D2C platform value beyond price, such as easier access and better adherence for their patients. On the consumer side, messaging should emphasize the value and convenience of online ordering, 24/7 online customer service, and free shipping to home, especially for recurring prescriptions.

Novo Nordisk is partnering with Costco to offer the retailer’s members Ozempic and Wegovy for $499 per month, or about half off what the medications cost patients without insurance. Novo tapping into Costco’s customer base of over 100 million US cardholders is a savvy play, especially considering that Costco members skew toward higher-income compared with shoppers generally. Novo and Costco can specifically market to new mothers and families broadly who may be struggling with weight gain due to their busy lives.

GoodRx is partnering with Kroger pharmacies to roll out a medication savings program for branded drugs, including Novo Nordisk’s Ozempic and Wegovy. Kroger has a great opportunity to market healthy food offerings through its grocery business to people picking up GLP-1 prescriptions at its pharmacy. This might involve pharmacist-led medication management, tailored marketing for store products that support GLP-1 use (e.g., high-protein, low-calorie, fiber-rich), and access to nutrition guidance and resources.

Telehealth company LifeMD is partnering with Novo Nordisk to offer diabetes patients Ozempic for $499 per month. GLP-1 price wars are taking place between drugmakers and online healthcare companies still selling compounded weight loss medications. Novo’s and Lilly’s branded drugs have the stamp of FDA approval in their favor, but many cost-conscious consumers paying out of pocket will still opt for the cheaper compounded GLP-1s (~$200 per month) through telehealth platforms like Hims & Hers.

AstraZeneca is launching a direct-to-consumer (D2C) website and dropping the cash-pay prices of two key drugs, following Bristol Myers Squibb’s announcement a day earlier. Pharma D2C is no longer a niche play and we expect direct sales to play a bigger role in future drug sales. The new models bypass insurers and pharmacy benefit manager middlemen, which should lead to better prices for consumers. Drugmakers and agencies also need to focus on creating well-designed, patient-centered website experiences that mirror online retail experiences—or risk losing out in what’s about to become a crowded pharma D2C marketplace.

Bristol Myers Squibb is expanding D2C drug sales with the launch of a new telehealth platform and a steep cash-pay discount for its psoriasis treatment Sotyktu.. The rise of drugmakers' telehealth platforms is reshaping the traditional path to prescriptions. However, the opportunity for pharma is building direct ties to consumers via affordability and convenience, while also navigating Trump administration involvement and regulatory scrutiny. Drugmakers need to design simple, transparent D2C telehealth websites that follow the letter of the law, minimize consumer confusion, and earn patients’ trust.